The Kilkis prefecture is located in central Makedonia , between the Prefectures of Pella , Thessaloniki and Serres . A large part of Kilkis lies around the verdant valley of the Axios River , the ancient Amfaxitida. Its western and northern regions include the sublime and forested mountains of Paiko and Belles, while Krousia on its north eastern side, and the Doirani Lake in the north and west , constitute a natural border as well as a splendid aquatic habitat with rare bird and plant species .
The region throughout appears to have been an area of human activity since the Copper and Iron Ages. Prehistoric settlements and interspersed tombs have provided significant findings dating back to the second millennium BC.
On the west lies Peonia, a site Homer referred to by naming Axios the earths widest and most beautiful river.

At the end of the archaic era, the region of the Kilkis prefecture came into the hands of the Macedonian state into the boundaries of the present Hellenic state.
Today, the region is restructured economically and culturally, and gladly embraces its visitor in its splendid areas, marked with natural beauty.
The people of the area are creative, hardworking and very hospitable. They are mostly occupied with agriculture, animal husbandry, industry and increasingly with tourism. Many crops are grown here including cereals, tobacco and cotton.
The capital of the county is Kilkis and other important towns include Goumenissa, Axioupoli and Polycastro.
The hill of Ai-Giorgis dominates the town of Kilkis, which is spread out at its feet. The post-Byzantine church of Aghios Georgios graces its summit built in 1832, it contains unusual wall paintings.
Just 6 kilometers southwest of Goumenissa are the village and archaeological site of Europos. The ancient kouros found here and on exhibit in the archaeological museum numbers among the most important finds of the region.
Also worth a visit is Palio Ginekokastro, where there is a ruined Byzantine fortress erected by Andronikos III Paleologos (1328-1341).
In the northern part of the prefecture is one of its jewels: Lake Doirani, a natural wonderland. One can swim in its waters and enjoy the idyllic hamlets built along its sandy shores. The tavernas at Doirari village serve delicacies fished from the lake.
The western section of the prefecture is mountainous. The ascent of Mt. Paiko (1,500 m. alt.) brings much to marvel at: thickly wooded slopes, rushing brooks and streams and delightful little villages, such as Griva, Kastaneri and Livadia.